GeneIII® L-Ergothioneine 30mg
GeneIII® delivers 30mg of clinically studied L-Ergothioneine, produced through patented fermentation to support restorative sleep, steady energy, cognitive health, and healthy aging.*
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FDA-Notified GRAS Ingredient
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30mg Clinically Studied Dosage
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99.99% Ultra-Pure L-Ergothioneine
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Patented Fermentation
Product Details
L-Ergothioneine is a naturally occurring compound found in foods like mushrooms, but unlike most antioxidants, your body has a dedicated transporter called OCTN1 that actively absorbs and retains it.
Research suggests it accumulates in areas exposed to high oxidative stress—including the brain, liver, eyes, and other highly active tissues—where it helps support cellular health and resilience.*
GeneIII® produces its L-Ergothioneine through proprietary patented fermentation and refines it to 99.99% purity, delivering exceptional consistency and quality in every capsule.
Key ingredients
Each capsule contains pure L-Ergothioneine (EGT). GeneIII is a science-backed, patented, award-winning, pure and vegan-friendly EGT supplement to support your long-term health and wellness.
No unnecessary fillers, artificial colors, or preservatives.
Why Ergothioneine?
L-Ergothioneine is a rare amino acid-derived antioxidant naturally found in small amounts in certain foods like mushrooms. What makes it unique is that the human body has a specific transporter, OCTN1, designed to absorb and retain it.
Research suggests L-Ergothioneine accumulates in tissues exposed to high levels of oxidative stress, where it helps support cellular protection and mitochondrial health.
Because the body actively retains it, many researchers consider L-Ergothioneine fundamentally different from conventional antioxidants.
How to use
Take 1-2 capsules daily, with or without a meal.
For best results, use consistently for at least 6–8 weeks.
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Measurable Improvements Within 30 Days*
*Based on a 30-day clinical study using biomarker and self-reported outcome measures. Results may vary.
Whole-Body Wellness
Clinical Study Results
Energy & Fatigue
Participants reported measurable improvements after 30 days of GeneIII L-Ergothioneine supplementation:
- 39% improvement in overall physical function, including reduced fatigue and improved recovery*
- 51.56% improvement in daytime energy levels*
- Improvements in sleep quality and how participants felt the next day*
Ovarian Health
In a 3-cycle clinical observation, participants showed measurable changes in markers associated with ovarian function:
- AMH levels improved (from 1.79 to 2.47 ng/mL after 3 cycles)*
- Significant improvements in cycle regularity and menstrual comfort*
- Reductions in symptoms commonly associated with hormonal imbalance*
Liver Health
In a 30-day clinical trial, participants taking 60mg of GeneIII L-Ergothioneine daily showed:
- Around 20% reduction in AST levels associated with liver stress*
- Around 21% reduction in ALT levels*
- 18% reduction in GGT levels after 30 days*
- Improvements in physical recovery and fatigue*
Postpartum Health
A placebo-controlled human clinical trial found that postpartum participants taking GeneIII L-Ergothioneine for 30 days experienced significant improvements compared to placebo
- 35.94% improvement in overall quality of life (SF-36)*
- 37.43% increase in daily vitality*
- 27.78% reduction in physical fatigue*
*Based on findings from registered human clinical studies and observational research on GeneIII L-Ergothioneine. Results may vary.
Backed by Rigorous Science and Uncompromising Standards
At GeneIII, we are dedicated to the highest standards in science, supplement quality and safety.
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$15M+ invested in clinical research
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Pure & patented L-EGT ingredient
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Highest-standard manufacturing
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Every batch independently tested
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FDA GRAS favorable review
Better Aging Starts at the Cellular Level
Deep, Restorative Sleep
Your body does its deepest repair at night. L-Ergothioneine is transported into cells involved in recovery and stress response, supporting more restful, uninterrupted sleep. In our 30-day clinical trial, 51% of participants reported fewer sleep disturbances.*
Improved Energy Levels
Energy without the crash. By protecting cells from everyday oxidative stress, L-Ergothioneine supports your mitochondria, the engines of cellular energy, helping you sustain steady focus and vitality throughout the day, no stimulants required.*
Cognitive Performance
Clarity starts at the cellular level. L-Ergothioneine accumulates in the brain through OCTN1, your body's dedicated transporter, where it helps support cognitive function, focus, and long-term brain health for years to come.*
Wow! I was honestly surprised at how much clearer my mind felt after taking this. I started with two a day like other reviewers suggested, and it really helped me with mental clarity. I noticed way less brain fog and better focus after taking this. So happy I added this to my routine!
Worked just as advertised - noticeably more energy since I began taking two pills per day… highly recommend!
I was amazed.I bought this product because I was curious about all the benefits I heard on Ergothioneine and decide to test it out myself. I was skeptical at first but after taking 2 capsules a day, I started waking up feeling more refreshed when I hit the 3 weeks mark. I did not change anything on my exercise or eating habit, so I know it must be this supplement.Would definitely recommend to try it out for increasing energy level and better sleep quality!
High quality, no fuss addition to my wellness routine. I’ve felt the antioxidative effects and love it.
As a physician I have been supplementing with a variety of mushroom products for many years. One of the most important properties mushrooms possess is ergothioneine, no debate here. It's great to have this quality product on board.
A very important nutient manufactured to quality standards at an appropriate dose by GeneIII.
The most efficient way to obtain the supplement vs mushrooms, which I use as well for wellbeing.
Head and shoulders over every Ergothioneine supplement. A classy product.
My friend has been using this for months and recommended it so I decided to give it a try. So far so good and worth the hype! I’m definitely feeling like I have more energy recently and sleep quality has improved. Highly recommend!
Really felt energized after taking these! No more morning/afternoon grogginess anymore. Can't wait to place another order!
I feel so much clearer and energized in the morning! Have already recommended to friends and fam - it’s noticeably improved our mood too
I didn’t feel an immediate boost, but after taking this for a couple of weeks, my energy felt more steady throughout the day, and I felt less run-down, especially on busy days. I’ve also been waking up less in the middle of the night, which was a nice surprise. I haven’t experienced any side effects, so I’ll definitely be ordering more!
Great
I did some research and found this to be an excellent brand. Third party testing is key. No way to know for sure if it’s working as it’s more of a wait and see as I age. Plus the studies on this ingredient is still small and bioavailability of benefits uncertain but I am all about insurance. Here’s hoping.
I bought this for my mom. She already takes CoQ10, and I was hoping this would enhance the mental clarity it provides. It has done a great job. She really feels like it is helping her remember more and that she is finally getting a good night's sleep, not waking up 7 or 8 times during the night. It is a regular-sized capsule, so it is easy to swallow. It is not really large. It doesn't have any nasty aftertaste either. She said she will continue to use it.
We heard Geneii is the leading brand of Ergothionine so we wanted to give it a try - it's awesome! We would 100% recommend to all family and friends and this listing is a great deal too :)
After taking this product for several weeks, I noticed a difference in focus and mental clarity. I felt sharper and also much more energized the next day after taking this. Would definitely recommend.
I thought I already had some A1 sleep quality, but with this supplement I was sleeping like a baby!! We're talking deepest REM cycles in the league. And waking up so refreshed every morning, had me ready to attack my Excel spreadsheets as soon as I rolled out of bed. Top tier product
I initially purchased this for better sleep, but the biggest improvement I felt was in mental sharpness after 1 month of taking it consistently. Really excited to continue!
I’ve been taking this supplement for two months now and I feel more energized! I am a naturally sleepy person but ergothioneine has helped me stay awake during the day and I feel more focused too. I highly recommend.
Working in a fast-paced environment, I'm always looking for an edge to keep me awake and my mind sharp. Coffee and Red Bull don't cut it for me anymore, so I tried Gene III on a friend's recommendation After a few weeks, I definitely felt the difference. Mentally, I feel quicker and sharper. Physically, my gut felt "cleaner." Highly recommended!
Helps with my skin and sleep
Feel like this product works, but is expensive. I may have noticed skin elasticity. Maybe energy. It’s hard to tell. I think the supplement is high quality, just not sure about the price yet.
GENEIII's L-Ergothioneine is a powerful antioxidant that helps to fight free radicals, helps to strengthen immune system and helps to support anti-aging. I like that this supplement is made in a food grade facility in the USA and undergoes third party testing. Serving size is one capsule and you get a 60-day supply. I like you get 30mg per serving. Really good quality supplement.
This supplement is a powerful antioxidant for fighting free radicals. It has been 3rd party tested and seems to have a lot of health benefits. This is a mushroom supplement in capsule form, easily swallowed with no after taste. Made in the USA !
I recently started using the L-Ergothioneine Supplement, and I am very pleased with the results! My shipment came in November, 2024 with an expiration date of 7/17/2027, so there is plenty of time to use them. Here are the things that I liked: This supplement is designed to support longevity, immune function, heart health, and brain health. Each serving contains 30mg of high-purity ergothioneine, which is known for its powerful antioxidant properties. I've noticed a significant improvement in my overall well-being since I started taking it. The capsules are easy to swallow and have no noticeable taste or odor. The ingredients in this supplement are of high quality. It is made in the USA in a food-grade facility and undergoes rigorous third-party testing to ensure purity and potency. The supplement is also non-GMO and free from common allergens, making it a safe choice for most people. Overall Experience: Overall, I am very satisfied with this supplement. It has become a part of my daily routine, helping me maintain my energy levels and support my immune system. I would highly recommend it to anyone looking for a high-quality ergothioneine supplement.
It helps with boosting and maintaining my energy level. No side effect observed. One bottle lasts for 2 month. Made and bottled in USA. The price is fair. I will recommend it. I will give a 5/5.
Most ergothioneine is produced as a derivative of breaking down of several mushroom species. The production of ergothioneine in this product is as efficient as I have been able to find after a fairly intensive search. If you are capable of understanding the complex biochemistry of this substance, you may be interested in doing your own research on this product. It is something I will buy again for myself.
I have a long time sleep problem. I also have tooth inflammation and blacken toenails problems. I ordered GENEIII’s L-ergothioneine 30 mg capsules last month and tried. It looks like very effective. I like it and would like to use it for a while longer. Because it is 30 mg, I think it should work with my problems very well. However, even it works so far so good, it still needs time to cure my illness. I will continue to take it and keep going forward with my review.
This L-Ergothioneine supplement is designed to deliver high-purity, potent antioxidant support for overall health and longevity. Ergothioneine, often referred to as a "longevity vitamin," is a standout ingredient here, with each capsule providing 30 mg of 99.99% pure ergothioneine, totaling an impressive 1500 mg per bottle. Its antioxidant capacity is remarkable, reportedly outclassing glutathione and other well-known antioxidants. Ergothioneine’s ability to penetrate cellular mitochondria and neutralize free radicals is particularly fascinating, offering targeted support for cellular health and energy production. Antioxidants like ergothioneine are crucial for combating oxidative stress, which can accelerate aging and impact skin, immune function, and cognitive health. This formula claims benefits ranging from improved stamina and skin elasticity to better brain health, including enhanced memory and mental clarity. The mention of potential benefits for sleep quality and stress-induced sleep issues also makes it appealing for those looking to optimize rest and recovery. It’s crafted in a food-grade facility and undergoes third-party testing for purity, ensuring safety and quality. The capsules are easy to take daily, with the option to mix the contents into meals or drinks for added convenience. After several weeks of consistent use, I noticed a slight improvement in energy levels and a more refreshed feeling after sleep. While subtle, these effects might hint at the deeper mitochondrial and cellular benefits of ergothioneine. Long-term use may reveal more pronounced results, particularly for skin, immune, and cognitive health. It's a bit pricy at $70 for a 2-month supply but is top-notch and much stronger than others I've tried. **As always, results can vary from person to person. Consulting a healthcare provider before starting any new supplement is advisable. Keep well (:
Frequently Asked Questions
What is L-Ergothioneine?
L-Ergothioneine (L-EGT) is a rare amino acid and powerful antioxidant naturally found in mushrooms. Unlike most antioxidants, your body has a dedicated transporter called OCTN1 specifically designed to absorb and retain it in areas with high oxidative stress, including the brain, liver, eyes, and skin.
Research suggests L-Ergothioneine may play an important role in supporting cellular health, healthy aging, cognitive function, and resilience against everyday oxidative stress.
Can't I just get L-Ergothioneine from food?
You can, but typically only in very small amounts.
L-Ergothioneine is primarily found in certain mushrooms, though levels vary significantly depending on species, growing conditions, storage, and preparation. To reach the amount found in a single GeneIII capsule, you may need to consume several hundred grams of mushrooms daily.
GeneIII uses a patented fermentation-based process to produce highly pure L-Ergothioneine with consistent potency and quality in every capsule.
How do I take GeneIII L-EGT?
Take 1-2 capsules daily, with or without food.
L-Ergothioneine is designed to build up in the body over time through the OCTN1 transporter system. Consistency matters more than timing, so we recommend taking it daily as part of your long-term wellness routine.
Why should I take GeneIII L-EGT?
Modern life exposes our cells to constant oxidative stress from aging, poor sleep, environmental factors, and everyday metabolism.
L-Ergothioneine helps support the body’s natural defense systems at the cellular level. GeneIII L-EGT is designed to support healthy aging, cognitive health, energy production, sleep quality, and overall cellular resilience.
What makes GeneIII different is our commitment to purity, research, and quality. We produce our own L-Ergothioneine using patented biotechnology and achieve 99.99% purity, backed by rigorous testing and registered human clinical research.
When will I feel something?
Everyone’s experience is different. Some people report noticing improvements in areas like energy, sleep quality, or overall well-being within a few weeks of consistent use, while others may notice more gradual changes over time.
Because L-Ergothioneine works at the cellular level, it is best thought of as a long-term investment in healthy aging and resilience, rather than a quick stimulant or temporary boost.
