L-Ergothioneine, the antioxidant that protects and powers your cells
As we age, our cells lose their ability to repair and renew. GeneIII’s ultra-pure, clinically studied L-Ergothioneine helps support cellular protection, natural energy, liver and brain health, skin vitality, and overall resilience.*
As We Age, Our Defenses Decline
Every second, trillions of your cells repair, renew, and generate energy through tiny powerhouses called mitochondria. But stress, lack of sleep, and aging increase oxidative damage that weakens these power sources over time.
From your early 20s, antioxidant defenses and mitochondrial performance naturally decrease. This gradual slowdown can lead to issues including fatigue, slower recovery, poor sleep, and liver strain. This is where one powerful antioxidant comes in: L-Ergothioneine.
L-Ergothioneine: The Essential Antioxidant
L-Ergothioneine (EGT) is a rare dietary antioxidant that your body cannot make. Yet, it is so important that humans evolved a special transporter (OCTN1) to absorb and preserve it in key tissues for long-term cellular protection. Explore what makes EGT unique, and how works inside your body:
1. Reaches the Brain for Deeper Protection
The OCTN1 transporter is expressed at the blood–brain barrier (BBB), allowing Ergothioneine to enter the brain and concentrate in regions that are especially vulnerable to oxidative stress. Very few dietary antioxidants can cross the BBB, highlighting EGT’s distinctive role in potentially supporting long-term brain health.
2. Concentrates Where Stress Is Highest
Ergothioneine accumulates in tissues that face high oxidative demands, including the liver, kidneys, red blood cells, seminal fluid, and lens of the eye. These are areas constantly exposed to toxins, oxygen, or light. By concentrating there, EGT provides localized antioxidant defense where resilience is most needed.
3. Passed From Mother to Child
The Ergothioneine transporter is present in the placenta, allowing mothers to transfer EGT to their babies during development. This prenatal supply suggests the nutrient is prioritized by the body from the very beginning of life.
4. Stored for Long-Term Cellular Defense
Unlike many antioxidants that are quickly used up and excreted, Ergothioneine is stored in tissues for extended periods. This long half-life creates a reservoir of protection that can be mobilized when oxidative stress levels rise, giving the body a lasting line of defense.
Why Supplementation Matters
Your body naturally stores L-Ergothioneine in vital tissues like the liver, eyes, and brain, but modern diets provide only trace amounts since its richest sources, mainly mushrooms, are rarely eaten. Supplementation is the most reliable way to ensure your cells get enough of this rare nutrient for lasting energy, resilience, and healthy aging.
Beyond Traditional Antioxidants
L-Ergothioneine works where other antioxidants can’t — protecting your cells from within to support your health.
Unlike typical antioxidants that react randomly in the body, L-Ergothioneine (EGT) is selectively taken up by your cells through a unique transporter (OCTN1). This means it goes exactly where protection is needed most. Your mitochondria, liver, brain, and skin, helping to preserve energy, focus, and resilience from the inside out.
EGT doesn’t just neutralize free radicals, it regulates oxidative stress and helps maintain balance. Think of it as your body’s built-in defense system upgrade: it identifies stress before it causes damage and restores equilibrium at the cellular level.
Decades of global research have confirmed L-Ergothioneine’s powerful protective effects against cellular aging, inflammation, and fatigue. Our patented fermentation process ensures 99.99% purity, cGMP production, and third-party testing for absolute quality and safety.
Modern lifestyles expose us to constant stress, pollution, and fatigue — all of which accelerate cellular decline. L-Ergothioneine helps your body adapt, repair, and recover, promoting long-term vitality and performance you can actually feel.
Backed by Science. Trusted by Experts.
Over 100 published studies have investigated the role of L-Ergothioneine in supporting mitochondrial health and longevity.
Ergothioneine Consumption and Longevity: Scientific Evidence
Studies show higher ergothioneine intake is associated with lower mortality, reduced neurological disease, and increased life expectancy across populations.
